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No firm evidence and no dose gradient could be established when comparing different doses of CrP with placebo for various weight loss measures (body weight, body mass index, percentage body fat composition, change in waist circumference). However, in order to find out if CrP works in general, we also analysed the effect of all pooled CrP doses versus placebo on body weight only.Īcross all CrP doses investigated (200 µg, 400 µg, 500 µg, 1000 µg) we noted an effect on body weight in favour of CrP of debatable clinical relevance after 12 to 16 weeks of treatment: mean difference (MD) -1.1 kg (95% CI -1.7 to -0.4) P = 0.001 392 participants 6 trials low-quality evidence (GRADE)). We focused this review on investigating which dose of CrP would prove most effective versus placebo and therefore assessed the results according to CrP dose. Three RCTs compared CrP plus resistance or weight training with placebo plus resistance or weight training, the other RCTs compared CrP alone versus placebo. The RCTs were conducted in the community setting, with interventions mainly delivered by health professionals, and had a short- to medium-term follow up (up to 24 weeks). We evaluated nine RCTs involving a total of 622 participants. ![]() The overall quality of evidence was considered low and we have inadequate information from which to draw conclusions about the efficacy and safety of chromium picolinate supplementation in overweight or obese adults. No study reported whether supplementation was associated with increases in deaths from any cause or illnesses (such as myocardial infarction or stroke), or the health-related quality of life or socioeconomic effects of supplementation. In addition, the length of studies included was rather short (maximum of 24 weeks), so we were unable to determine any long-term effects of supplementation. Only three of nine studies provided information on adverse events, so we were unable to determine whether chromium picolinate supplements are safe and whether any potential harms may increase with dose. We were unable to find good evidence that this potential weight loss effect increased with increasing dose of chromium picolinate. When the results obtained from the doses of chromium picolinate investigated (200 µg, 400 µg, 500 µg, 1000 µg) were pooled, study participants lost around 1 kg of body weight more than participants receiving placebo. The evidence is current to December 2012. A total of 622 participants took part in the studies, 346 participants received chromium picolinate and 276 received placebo. with a body mass index between 25 and 29.9 kg/m 2 defining being overweight and a body mass index of 30kg/m 2 or more defining obesity). We included nine randomised controlled trials which compared the efficacy and safety of 8 to 24 weeks of chromium supplementation and placebo in overweight or obese adults (i.e. Chromium picolinate is one of several chemical compounds of chromium sold as a nutritional supplement as a potential aid to weight loss. Chromium is also said to suppress the appetite and stimulate the production of heat by the body, thus increasing energy expenditure. It is generally believed that chromium may help to reduce a person's weight by decreasing the amount of fat in the body. ![]() Chromium increases the activity of insulin, and dietary supplementation with chromium has produced improvements in glucose metabolism which may lower blood glucose being important for overweight people with diabetes. the chemical reactions involved in breaking down these molecules to a form suitable for absorption by the body). Are chromium supplements useful for reducing body weight in overweight or obese adults?Ĭhromium is an essential nutrient (trace element) required for the normal metabolism of carbohydrate, protein and fat (i.e.
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